Allergies: Complex Holistic Dysfunctions

Paul L. Reller L.Ac. / Last Updated: August 03, 2017

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Information Resources: Additional Information and Links to Scientific Studies

Treatment with Complementary and Alternative Medicine for allergies in Europe is proving very successful and well utilized. Some of the data on the practice and research support is listed below with links to published data.

  1. A 2009 overview of food allergy pathophysiology by experts at Mount Sinai Hospital in New York, New York, U.S.A. is extensive yet concise in outlining what was known at that time about pediatric food allergies, which present a broad spectrum of disorders and symptoms, with childhood allergic sensitization to peanuts, nuts, egg and dairy often persisting into adulthood. The importance of a healthy gut membrane and immune response, problems with the simple advice to just avoid allergens, contributors to risk that include medications that contribute to gastrointestinal dysfunction, NSAIDS, acetaminophen, steroids and antidepressants, lack of exercise, and glycosylation of foods such as peanuts by cooking with sugars and fats (creating AGEs). These experts note that there are no standard medications to treat pediatric food allergies, primarily a failure of the host immune response, and that evidence-based new therapies include Chinese Herbal Medicine, citing a 9-herb formula called FAHF-2 for peanut allergies: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2831568/
  2. A 2009 study at the University of Messina School of Medicine, in Italy, showed that infants whose immune system was challenged with pediatric sepsis showed significantly less incidence of allergies later in life. Such study demonstrates that attention to immune health is the most important factor in preventing allergic disease, and a more holistic approach is needed. The standard practice of avoidance of allergens and potential allergens, overuse of antibiotics, and overuse of antihistamines and steroid medications has been a disaster, ignoring the basics of allergic pathophysiology: http://www.geneticapediatrica.it/archivi/2011/archivio3/page.php?id=11
  3. A 2013 article in the Canadian Family Physician, by Dr. Eilssa Michele Abrams, noted pediatric immunologist at the University of Manitoba, in Winnipeg, Canada, shows that prior narrow allopathic views of childhood allergies and prevention, with avoidance of the most common food allergens in pregnancy and early infancy were completely and astoundingly wrong. Numerous studies have finally convinced standard medicine that a more holistic approach, with healthy introduction of allergens in a step-by-step manner in infancy, avoidance of too complex and processed foods early in life, and exposure to foods in pregnancy, all contribute to a healthy adaptive immune system: http://www.cfp.ca/content/59/7/721.full
  4. A 2013 meta-review of all scientific studies of corticosteroids in the treatment of allergic sinusitis, by experts at the University of Utrecht, in The Netherlands, showed that almost all studies show no evidence of benefit, and the 3 small human clinical trials of corticosteroid nasal sprays that showed a mild benefit had a high risk of bias and low standard of evidence. Only one small human clinical trial provided the evidence that is used to universally prescribe this problematic medical treatment. Ignoring the evidence of benefit from safe and effective herbal medicine seems misguided, especially as numerous studies have now shown that chronic use of antihistamines will likely worsen the rhinosinusitis over time: http://www.ncbi.nlm.nih.gov/pubmed/24013138
  5. A 2013 meta-review of all scientific studies of antibiotics in the treatment of allergic sinusitis, by experts at the University of Utrecht, in The Netherlands, showed that almost all studies show no evidence of benefit, and the few small human clinical trials used to support this treatment were of poor quality, did not compare to placebo, used a select subset of patients to improve study results, and purposely excluded the study results concerning patients with recurrent acute episodes of rhinosinusitis, who could have experienced increased risk of such acute alarming episodes from the use of antibiotics, antihistamines and corticosteroids: http://www.ncbi.nlm.nih.gov/pubmed/24065207
  6. A 2005 study at the Medical University Vienna in Austria found that common prescription medications to treat stomach acidity produced an increased sensitization to food allergens in 25 percent of patients within 3 months of use. An alternative to these histamine and gastric acid blocking chemicals is a formula of nutrient and herbal medicine that may restore normal gastric function and homeostasis: http://www.ncbi.nlm.nih.gov/pubmed/15671152
  7. A 2006 follow-up study at the Medical University Vienna in Austria found that gastric hypofunction was highly related to food allergen sensitization, as well as the development of the phases of food allergic reactivity. The common prescription of chemicals to block gastric function to reduce symptoms of poor stomach acid function has resulted in a high number of individuals in developed countries with serious food allergies, compounding the problems. Restoration of gastric homeostasis with herbal and nutrient medicine could both resolve GERD and heartburn, and help to decrease chronic allergic sinusitis and other allergic syndromes, and this study showed that chronic allergic syndromes often are comorbid with gastric hypofunction: http://www.ncbi.nlm.nih.gov/pubmed/16670517
  8. A 2008 study at the Medical University Vienna found that gastric acid inhibiting medications increase the gastric pH and substantially reduce the gastric digestive function, leading to poor protein digestion and increased risk of food allergies, almost all of which are related to food proteins and peptides: http://www.ncbi.nlm.nih.gov/pubmed/18539189
  9. A 2014 study at the Pierre and Marie Curie University, in Paris, France, one of the leading research institutions in exploring chronic inflammatory, allergic and metabolic diseases, showed that the 2 most important determinants of a lifetime of allergic rhinitis and asthma acquired in childhood were mold and fungi exposure and peanut sensitization, with food allergy and hypersensitivity leading to respiratory allergy: http://www.ncbi.nlm.nih.gov/pubmed/24831804
  10. A 2003 meta-review of peanut allergy, by McGill University Health Centre, in Montreal, Quebec, Canada, revealed that a dramatic increase in childhood peanut allergy occurred between 1997 and 2002, and that this prevalence increased the risk for allergic rhinitis and asthma four-fold, and would be a lifelong problem for over 90 percent of the children with peanut sensitization: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC154188/
  11. A 2004 study at the University of Southern California Keck School of Medicine showed that exposure to herbicides and pesticides were among the highest predictors for childhood allergic asthma, and the promise of reduced herbicide with GMO crops matched to glyphosate herbicides is now proven to have been a lie, with just the opposite occurring, and superweeds developed with herbicide resistance requiring more herbicide and pesticide in the future: http://www.ncbi.nlm.nih.gov/pubmed/15121522
  12. A 2015 reversal of guidelines for childhood peanut allergies was published by the U.S. National Institute of Allergy and Infectious Diseases, with evidence showing that avoidance of peanuts in infant diets was the wrong approach, and that introduction of some peanuts into the diet after 6 months of age and advancing from breast feeding produces an 80 percent reduction in risk of developing the peanut allergy, showing that strengthening the immune system and immune memory is all-important in allergic disease, not the avoidance of the food allergen. This randomized controlled human clinical trial involved more than 600 infants at high-risk of acquiring the peanut allergy: http://www.niaid.nih.gov/news/newsreleases/2015/Pages/LEAP.aspx
  13. A 2013 study by the Boston Children's Hospital, Boston, Massachusetts, U.S.A. showed that mothers who consumed peanuts during their pregnancy and while nursing significantly decreased the risk that their child would develop a peanut allergy, completely reversing the advice to avoid peanuts by the American Pediatric Association in 2000, which ironically could have led to the some of the dramatic increases in peanut allergies in children from 1997 t0 2009. Once again, the idea that allergies are purely a problem of the allergen and not the host immune health is an allopathic idea that has been widely accepted, but is wrong. Holistic medicine emphasizes the need to strengthen the host immune system to counter allergies: http://www.childrenshospital.org/news-and-events/2013/december-2013/pregnant-women-need-not-avoid-peanuts-evidence-shows
  14. A 2008 study by the Division of Immunology at Children's Hospital in Boston, Massachusetts, U.S.A. examined the records of 432 children with a parental history of atopy (genetic or epigenetic disposition to develop an allergic reaction) to see if there exists a strong relationship between caesarian birth and childhood allergic rhinits and allergic sensitization. The study found that caesarian birth is associated with 2-fold higher odds of atopy (genetic propensity for allergies) and a significantly increased risk of acquiring allergic rhinitis, but not allergic asthma. These experts concluded that the lack of symbiotic bacterial exposure obtained via vaginal delivery was responsible, implying that the biota, or colony of symbiotic bacteria in the gut and membranes was very important in preventing allergies: http://www.ncbi.nlm.nih.gov/pubmed/18571710
  15. A 2011 long-term study of 37,171 children enrolled in the Norwegian Mother and Child Cohort study, sponsored by the Norwegian Institute of Public Health, adjusted data for all contributing factors and concluded that children born of caesarian section had a significantly increased risk for allergic asthma at 36 months of age, and was slightly higher for mothers without a family history of allergies: http://aje.oxfordjournals.org/content/174/11/1275.full
  16. A large multi-center 2005 study at Harvard Medical School, Tufts, the Mallman School of Medicine at Columbia University, and Brigham and Women's Hospital in Boston, Massachusetts, an New York, New York, U.S.A. found that childhood sensitization to various pathogenic molds and fungi were predictive of future allergic rhinitis and asthma, with specific dust-borne pathogenic fungi in the air of homes in the first 3 months of life associated with increased risk of developing a serious allergic rhinitis by age 5, which is associated with future allergic asthma, insomnia, and sleep apnea: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1281288/
  17. A 2015 study at the Icahn School of Medicine at Mount Sinai, in New York, New York, USA, and the National Jewish Health Center, in Denver, Colorado, found that new paradigms in treatment and diagnosis of allergies and hypersensitivity reactions are presenting important guidance in this field. For instance, worrisome increases in peanut allergy and food-induced anaphylaxis, associated with environmental exposure to house dust and fungal mold and mildews, as well as a rise in eczema in children with impaired skin barrier health, are presenting a mounting problem (associated with aspergillus on peanuts and hypersensitivity to this on commercial peanut products, as well as airborne peanut dust with such fungal aspects). Better testing of immunotherapy to guide its use in therapeutic protocol, as well as HLA phenotyping to discover individuals with genetic propensities to drug and other allergies is progressing: http://www.ncbi.nlm.nih.gov/pubmed/25662305
  18. A 1997 German Multicenter Allergy Study found that sensitization to chicken egg specific IgE in infants under the age of 3 years, especially when combined with a family history of atopy (genetic or epigenetic predisposition of allergies) was highly predictive for future allergic rhinitis, asthma and eczema. These researchers found that the level of IgE in the blood of the umbilical cord was not associated with future allergies. Such studies show the profound connections between the gut immune response and allergic syndromes of the sinus, bronchiole and skin membranes. The precautionary advice would be to be careful when introducing more complex foods to a child at an early age: http://www.sciencedirect.com/science/article/pii/S0091674997700216
  19. A 2013 multicenter study at the Feinberg School of Medicine at Northwestern University in Chicago, Illinois, U.S.A., National Cheng Kung University, in Tainan, Taiwan, and National Yang-Ming University in Taiwan, found that early infant and childhood exposure to antibiotics and acetaminofen was predictive for future allergic rhinitis, asthma and atopic dermatitis (eczema): http://www.ncbi.nlm.nih.gov/pubmed/24062298
  20. A 2009 study at the General Hospital of Athens, Greece, found that a history of aspirin-related respiratory disease was as strong predictor of poor outcomes for normal sinus function after endoscopic sinus surgery in adults to correct nasal polyps: http://www.ncbi.nlm.nih.gov/pubmed/19490814
  21. A large 2014 study at Northwestern University, in Chicago, Illinois, U.S.A. showed that children with allergic disorders had a higher prevalence of various comorbid psychological and behavioral disorders, including ADHD, anxiety and depressive mood disorders, and conduct/oppositional defiant disorder. Unfortunately, an increasing prescription of amphetamine ADHD drugs are being prescribed, as well as anti-anxiety and anti-psychotic medications, even in children younger than 3 years of age, despite these protocols not being approved as safe or effective by the U.S. FDA: http://www.ncbi.nlm.nih.gov/pubmed/24713577
  22. A large 2014 study at Northwestern University, in Chicago, Illinois, as well as Besth Israel Medical Center in New York, U.S.A. found that there was increased prevalence of future epilepsy for children with allergic diseases: http://www.ncbi.nlm.nih.gov/pubmed/24251558
  23. A 2014 randomized controlled human clinical trial in China showed that simple pediatric herbal formulas to treat asthma and allergy were as effective as standard leukotriene receptor antagonists and bronchiodilators in downregulating Il-4 and CysLTR1, and upregulating interferon gamma response. These pediatric herbal formulas present no adverse side effects, unlike the pharmaceuticals: http://www.ncbi.nlm.nih.gov/pubmed/24660603
  24. Current use of Immunotherapy in European clinics is very successful. In 2013, the University of North Carolina at Chapel Hill School of Medicine reviewed the options available to patients in the United States: http://www.ncbi.nlm.nih.gov/pubmed/23498595
  25. Testing for true allergies has always been problematic, and so many questionable methods have been devised and some have become popular, apparently working for a wide variety of patients despite a lack of scientific proof of efficacy. Unfortunately, some of these methods have been linked to acupressure and acupuncture, but not be the field of professional acupuncture, or the TCM specialty. As this FARE website shows, there is now quite the industry involved in selling unproven allergy testing and treatment, and some of the well known methods, such as NAET, were developed and heavily marketed by physicians that only claim to have studied acupuncture, casting a bad light on the acupuncture profession: http://www.foodallergy.org/diagnosis-testing/unproven-testing
  26. Current use of Complementary and Alternative Medicine by medical doctors in Europe as far back as 2002 proves that this treatment protocol works for a growing body of patients: http://www.ncbi.nlm.nih.gov/pubmed/12121187
  27. By 2004 studies showed that 30% of all patients with in Europe chose to treat with Complementary and Integrative Medicine (CIM), with a great percentage choosing acupuncture and herbal medicine: http://www.ncbi.nlm.nih.gov/pubmed/15330007
  28. A 2015 meta-review of all published scientific studies of acupuncture stimulation in the treatment of allergic disorders, that met the highest levels of quality criteria, was conducted by Medical Doctors at the Shanghai Jiaotong University School of Medicine. The conclusion shows that acupuncture stimulation alone presented significant reduction of symptoms and measurable immune benefits, reductions in the need for constant problematic antihistamines and steroid drugs, as well as long-term improvement in Quality of Life: http://www.ncbi.nlm.nih.gov/pubmed/25590322
  29. A 2014 study of the cost-effectiveness for integration of acupuncture in the treatment of patients with allergic asthma, by Charite'-University Medical Center, in Berlin, Germany, Institute for Social Medicine, found that adding a short course of acupuncture therapy to the care of patients with allergic asthma resulted in cost effectiveness in terms of quality of life (QALY) as well as improved outcomes of therapy. The resulting Incremental Cost-Effectiveness Ratio (ICER) averaged about 24,000 Euros per patient (lifetime) in this randomized controlled human clinical trial with 306 patients: http://www.ncbi.nlm.nih.gov/pubmed/24256028
  30. A 2014 randomized controlled human clinical trial of acupuncture needle stimulation versus treatment with Loratadine (Claritin) for the treatment of patients with allergy to dust mites, conducted at the University Hospital of the Dresden University of Technology, in Germany, and concluded that "acupuncture is an effective, well-tolerated form of therapy in the treatment of patients suffering from the dust mite allergy with its effect being comparable to loratadine (Claritin)". The measures studied included not just symptom relief, but immune cytokines and antibody levels, proving beyond a shadow of a doubt that the effect was not just a subjective placebo effect: http://www.hindawi.com/journals/ja/2014/654632/
  31. A 2000 randomized controlled human clinical trial of acupuncture in the integrated treatment for allergic asthma, at the University of Heidelberg School of Music, showed that short courses of acupuncture provided an array of significant benefits in a course of 12 treatments over 4 weeks. Measurable benefits included immune modulation with improved lymphocyte complements, decrease in inflammatory cytokines IL-6, Il-10, and increase in anti-inflammatory cytokine IL-8, with a significant decrease in eosinophils, none of which occurred in the control group. Such modulation of homeostatic immune effects cannot be achieved with pharmaceutical medication: http://www.ncbi.nlm.nih.gov/pubmed/11152056
  32. This website on Childhood Allergies from the renowned Johns Hopkins University Medical School includes an announcement that they are excited about a study beginning in 2014 that combines immunotherapy and herbal medicine to prove that this approach is effective. These Complementary Medicine therapies were derided in standard medicine just a few years ago, but are becoming the hope for the future in Integrative Medicine, and present low-cost and perfectly safe therapies: http://www.hopkinschildrens.org/tpl_nav1up_nav2up.aspx?id=7920
  33. A 2015 revision of clinical practice guidelines for allergic rhinitis, by experts at 18 well-known standard treatment centers, including Johns Hopkins, Georgetown University, the University of Utah, Louisiana State University, St. Louis University, the University of Chicago, and the Birmingham VA Medical Center, now includes acupuncture and the referral to a Licensed Acupuncturist: http://www.ncbi.nlm.nih.gov/pubmed/25644617
  34. A 2014 meta-review of acupuncture for the treatment of allergic disease, by experts at the Technical University of Munich, in Germany, found that "acupuncture plays an increasingly important role as evidence-based therapy for allergy relief and can be recommended as adjunct therapy for allergic rhinitis. Specifically for allergic rhinitis and asthma, acupuncture can be cost-effective in terms of money spent per quality of life gained". Nuf said: http://www.ncbi.nlm.nih.gov/pubmed/24881629
  35. A 2012 randomized controlled study at Liaoning University of TCM, in Shenyang, China, showed that acupuncture at the point ST36 promotes a decrease in excess eosinophils and regulation of key inflammatory mediators such as Fas mRNA and Bcl-2 mRNA in asthma. Such study shows how a complete and holistic course of TCM treatment could relieve the underlying pathology with just short courses of acupuncture and persistent individualized herbal medicine: http://www.ncbi.nlm.nih.gov/pubmed/23072095
  36. A 2013 study at the Shanghai University of Traditional Chinese Medicine found that acupuncture stimulation at the points DU14, UB12 and UB13, most useful to directly treat respiratory disease, stimulated with a fast rotation every 10 minutes during a 30 minute treatment, performed every other day for a short course of treatment over 5 weeks, resulted in a significant decrease in circulating eosinophils, IgA in saliva, IgE in blood, and T cell IL-2R, as well as other important markers of chronic allergic asthma. The trouble with such therapy in the U.S. and Europe is that it is performed only once per week to once per month, achieving small results: http://www.ncbi.nlm.nih.gov/pubmed/22661215
  37. A 2013 study at the Daejeon University College of Korean Medicine found that the Chinese herb magnolia (Xin yin hua) significantly inhibited the inflammatory leukotrienes IL-4 and IL-13, like current leukotriene inhibitors in pharmaceutical practice. Such herbal extracts are combined with herbal bronchiodilators and immune stimulants to create gentle and effective herbal formulas: http://www.ncbi.nlm.nih.gov/pubmed/23949779
  38. A 2013 study at the Icahn School of Medicine at Mount Sinai Department of Pediatrics, in New York, New York, U.S.A. found that a simple pediatric Chinese herbal formula, consisting of Ling zhi (Reishi), Ku shen and Gan cao (licorice root) inhibited production of IL-4 and IL-5 by TH-2 cells, as well as eotaxin-1 production by HLF-1 cells, providing significant anti-asthma and anti-allergy effects: http://www.ncbi.nlm.nih.gov/pubmed/23743163
  39. A 2013 large randomized controlled human clinical trial of acupuncture to treat allergic sinusitis, published in the Annals of Internal Medicine, showed that acupuncture treatment integrated with antihistamine use relieved symptoms in patients with seasonal allergic rhinitis and IgE sensitization better than common nasal spray pharmaceuticals (second generation antihistamine combined with corticosteroid) alone, and sham acupuncture. The patients reported less use of problematic antihistamines, and an 8-week follow-up noted long-term benefits: https://annals.org/article.aspx?articleid=1583578
  40. A German study at the Medical University of Lubeck found that patients who chose Complementary and Alternative Medicine to treat allergies were motivated by concern for Quality of Life and desire to take control of their health: http://www.ncbi.nlm.nih.gov/pubmed/14642985
  41. A Japanese study in 2010 found that when patients spent time in nature, such as parks and forests, that their immune system functioned better due to inhaling phytochemicals that plants create to protect them from the harmful effects of antigens, allergens and insects. These same phytochemicals are available in herbal medicines, especially alcohol and glycerite tinctures of the aerial parts of the herbs: http://www.nytimes.com/2010/07/06/health/06real.html?_r=1
  42. A 2008 meta-analysis of the effectiveness of acupuncture in the treatment of allergies in Germany, tested with double-blinded placebo trials, demonstrate the proven benefits: http://www.ncbi.nlm.nih.gov/pubmed/19055209
  43. A 2006 meta-analysis in Australia of current clinical trials and evidence supporting the use of acupuncture and herbal medicine in the treatment of allergic rhinitis (sinus allergy): http://www.ncbi.nlm.nih.gov/pubmed/16670510
  44. A 2009 meta-analysis of published studies of the efficacy of acupuncture to treat allergic rhinitis or sinusitis, by the Charite University Medical Center, in Berlin, Germany, found that at that time there were a limited number of studies of sufficient size (more than 30 patients), but that these published studies were sound randomized controlled human clinical studies, and demonstrated efficacy of acupuncture for perennial allergic rhinitis (PAR), with specific effects proven. These researchers noted that there is an urgent need to finance larger human clinical trials to demonstrate that even a small course of 6 treatments is indeed effective in the treatment protocol, which may result in greater utilization of this safe and cost-effective integrative treatment protocol: http://www.ncbi.nlm.nih.gov/pubmed/20609633
  45. A 2010 study at the esteemed Mount Sinai School of Medicine in New York found that a common Chinese herbal formula used to treat food allergies, called food allergy formula 2 (FAHF-2) in the study, found that this formula effectively reduced mast cell and basophil numbers and suppressed IgE-mediated mast cell activation to effectively protect against such food allergic reactions as peanut anaphylaxis. FAHF-2 consists of 9 common Chinese herbs, and is derived from the classic formula Wu mei wan, which is composed of Wu mei, Huai jiao, Xi xin, Huang lian, Huang bai, Zhi fu zi, Gui zhi, Gan jiang, Ren shen, and Dang gui, although the processed Fu zi is rarely used today. Standard medicine has produced no viable safe pharmaceutical approach to these threatening food allergies. Integration of Traditional Chinese Medicine would seen a sensible approach: http:/www.ncbi.nlm.nih.gov/pubmed/21134573
  46. This food allergy formula 2 mentioned above was studied in 2009 at Mount Sinai School of Medicine and found to provide long-term protection from anaphylaxis (severe food allergy) by inducing a beneficial shift in allergen-specific immune responses mediated largely by CD-8 T-cell interferon gamma (IFN-g) production. These effects lasted for 36 weeks after discontinuing the treatment of 7 weeks of formula, and reduced specific IgE antibodies to strong food allergens by 50 percent: http://www.ncbi.nlm.nih.gov/pubmed/19203662
  47. For a full view of one of the Mount Sinai School of Medicine in New York studies of this common and classic Chinese herbal food allergy formulas, Wu mei wan, or FAHF-2, click on this link to the U.S. National Institutes of Health government website of medical studies, or copy the address below and paste it to your server. The research found that this Chinese herbal formula exerted significant anti-histamine effects, reduced expression of membrane mast cells, and IgE reactivity to peanut allergy in laboratory animals: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059770/
  48. A 2013 meta-review of scientific studies of herbal medicine to treat allergic rhinitis (sinus allergy), found that 22 studies published in English language and Chinese medical journals showed that Traditional Chinese Medicine (TCM), usually combining acupuncture with herbal medicine, demonstrated effects of anti-allergic, anti-inflammatory, and immune modulation were combined, with anti-histamine effects of mast cells, effects of inhibition of inflammatory cytokines, and downregulation of IgE levels in circulation, or the downregulation of lymphocytes or macrophage expression. All of these studies demonstrated safety and minimal or no adverse effects: http://www.ncbi.nlm.nih.gov/pubmed/23422202
  49. A 2012 meta-review of scientific study of Chinese Herbal Medicine for the treatment of persistent allergic rhinities (sinus allergy), at Jiangsu University, Zhenjiang, China, found 7 randomized, controlled, human clinical trials published in medical journals, that confirmed proof that Chinese Herbal Medicine reduced symptoms greater than placebo, and exerted inhibition of IgE in circulation better than placebo: http://www.ncbi.nlm.nih.gov/pubmed/22435619
  50. A 2012 study of herbal treatment of mucosal imbalances in allergic rhinitis or sinusitis by Ghent University Hospital, Department of Oto-Rhino-Laryngology, in Ghent, Belgium, found that a combination of the Chinese herbs Scutellaria baicalensis (Huang qin) and Eleutherococcus senticosus (Siberian gingseng), exerted a potent anti-inflammatory effect on human mucosal tissues, inhibiting histamine release, IL-5, and prostaglandin D2, as well as other related inflammatory cytokines. These effects were shown to be comparable to, or superior to, an established corticosteroid inhaler. High dose Vitamin C was shown to increase mucosal function, and could be a beneficial addition to this herbal protocol. (An example of clinical protocol: a combination of Goldenseal and Siberian ginseng tinctures from Heron's Botanicals, with Astra C formula from Health Concerns): http://www.ncbi.nlm.nih.gov/pubmed/22272213
  51. A 2010 study at Kyung Hee University, South Korea, found that a Chinese herb Corydalis hereocarpa (Yi guo huang jin), with the active chemical Libanoridin, effectively inhibits allergic inflammatory response by the inflammatory mediators found to be excessive in the allergic responses, IL-1beta, IL-6, IL-8 and TNF-alpha: http://www.ncbi.nlm.nih.gov/pubmed/20100031
  52. A 2007 study at the Chosun University Medical School in Gwangju, South Korea, found that Quercetin, an antioxidant chemical found in a number of Chinese herbs, including Sang ji sheng (Loranthus parasiticus), Fan shi liu (Psidium guajava fruit), Di er cao (Hypericum, or St. John's wort), and Man shan hong (Rhododendrum dahuricum), and available in a purified extract, effectively treats allergic inflammatory responses by decreasing the inflammatory mediators IL-6, IL-8, TNF-alpha, and attenuating NF-kappaB and p38 chemokines. An optimized Resveratrol formula with purified Quercetin is available from Vitamin Research Products: http://www.ncbi.nlm.nih.gov/pubmed/17588137
  53. A 2013 study at the University of Tokoshima Graduate School, Institute of Health Biosciences, in Tokoshima, Japan, found that the Chinese herbal chemical quercetin inhibits upregulation of a problematic histamine H1 receptor to decrease the severity of histamine swelling in allergic rhinosinuvitis. The researchers noted that this is just one of the evidenced biological activities showing that quercetin has an array of effects to treat allergy symptoms: http://www.ncbi.nlm.nih.gov/pubmed/23333628
  54. A 2007 study at Kyung Hee University in Seoul, South Korea, also found that green tea, with the active chemical epigallocatechin gallate (EGCG), was an effective addition to an allergy regimen, inhbiting the production of the inflammatory mediators that drive allergic responses, IL-6, IL-8, and TNF-alpha, through inhibition of intracellular calcium ion triggering. Standardized green tea EGCG is included in a number of herbal and nutrient medicines today, as the benefits of ECGC in both cardiovascular health and weight loss are well documented. Green tea refers to the leaves of the herb Camellia sinensis, and oxidized black tea is popular due to the long preserved state of the herbal leaves, but this processing breaks down the ECGC. Nevertheless, black tea Camellia sinensis has also been found to have significant benefits for cardiovascular health, but that addition of milk to the black tea may prevent this vascular protection (Mario Lorenz et al, 2006; Berlin University Medical School): http://www.ncbi.nlm.nih.gov/pubmed/17135765
  55. A 2010 study at the Tunghai University in Taiwan found that the Chinese herb Anoetochilus formosanus (Jin xian lian) effectively modulates inflammatory allergic responses by modulating immune cytokines in allergic asthma, reducing IgE responses, and airway hyperresponsiveness: http://www.ncbi.nlm.nih.gov/pubmed/20092984
  56. A 2010 study at Mount Sinai School of Medicine, in New York, found that the TCM formula entitled Food Allergy Formula-2, or FAF-2, reduced basophils and mast cell numbers as well as suppressing IgE-mediated mast cell activation to inhibit allergic responses to food allergens: http://www.ncbi.nlm.nih.gov/pubmed/21134573
  57. A 2008 explanation of the Chinese Herbal Formula FAF-2, consisting of Ling zhi (Reishi mushroom), Wu mei (prune mume fruit), Huang lian (Coptidis), Ren shen (ginseng), Huang bai (phellodendrum), Gan jiang (aged ginger), Dang gui (Angelica sinensis), Gui zhi (Cinnamon), and Chuan jiao (zanthoxylum), and the clinical trials and other studies that proved its efficacy with food allergies: https://www.sciencebasedmedicine.org/an-herbal-cure-for-peanut-allergy/
  58. Legislators such as Congresswoman Nita Lowey have been insisting on greater attention to the fast-growing threat of food allergies since 2008, which cause a wide variety of health problems, not only acute digestive and skin reactions, but chronic respiratory congestion, and angioedema. As Congresswoman Lowey reports, the Centers for Disease Control admits that the mechanisms by which people develop food specific allergic reactions are still largely unknown: http://lowey.house.gov/index.cfm?sectionid=18&parentid=17§iontree=17,18&itemid=383
  59. A 2012 review of scientific literature concerning the homeostasis of gastric acid and the complex hormonal feedback that regulates it by Virginia Commonwealth University Health System in Richmond, Virginia, reveals that modern medicine still has an incomplete understanding of the complex homeostatic mechanisms of gastric acid secretion. They acknowledge that normal and healthy gastric acid secretion is vitally important to digestion of difficult proteins, as well as absorption of a number of very important molecules vital to our health and well being. Gastric acid secretion also plays a vital role in immune protections and control of allergies. 5 systems interact to regulate the secretion of gastric acid: neural, hormonal, paracrine, chemical, and bacterial (biotic), and dysfunction of this complex array of systems is implicated in a number of common diseases. The implication is that restoration of gastric homeostasis is very important to our health: http://www.ncbi.nlm.nih.gov/pubmed/22954692